منابع مشابه
Achilles' heel of triple negative cancer
Commentary on: Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer Breast cancer is the most commonly diagnosed tumor in women. While important advances in this field led to progressive increases in survival, in the metastatic setting the disease remains incurable. Because of this, important efforts are being carri...
متن کاملErratum: Achilles' heel of triple negative cancer
[This corrects the article on p. 115 in vol. 1, PMID: 25594005.][This corrects the article on p. 763 in vol. 1, PMID: 25621292.].
متن کاملRibosome biogenesis: Achilles heel of cancer?
It is long been known that cancer and non-cancer cells can be distinguished on the basis of their nucleolar morphologies. As early as the 19 th century, it was reported that cancer cells have larger and more irregularly shaped nucleoli. Since then, pathologists have used nucleolar morphology to predict the clinical outcome [1]. Nucleolar morphology is altered due to the up-regulation of ribosom...
متن کاملA new Achilles Heel in breast cancer?
The female sex hormones, estrogens (E) and progesterone (P) are major determinants of postnatal mammary gland development and are thought to promote breast carcinogenesis. How do they impact on the human breast? The most widely used models to study E and P signaling are hormone receptor positive breast cancer cell lines. However, it is unclear to what extent they provide insights into the breas...
متن کاملCancer's new Achilles' heel?
Claims to the discovery of cancers Achilles’ heel are multiple, even clichéd. Analogies to this Greek myth usually refer to the fall of the undefeatable, yet the novelty behind the legend is that a seemingly immortal foe could be toppled by something so innocuous as his heel. This may be the case for cancer and a non-coding mitochondrial RNA that as yet has no known physiological function or me...
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ژورنال
عنوان ژورنال: Nature
سال: 2001
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35091170